I have never been a big fan of Trade Skill Master. My original perception was that it was hard to learn, offered limited flexibility and was geared primarily to Glyph production and maintenance of Glyph auctions. Since I wasn't active in Glyph sales I shied away from TSM.
My opinion hasn't changed that much. However, I did decide to try my hand at Glyphs since I know all but 4 of the patterns. So far, TSM has proven very useful in both producing Glyphs and maintaining their auctions. It was fairly cumbersome to learn but has proven surprisingly nimble in managing Glyph auctions as well as my other regular postings.
Today I stumbled upon an application for TSM that proved a huge time savings for me. It may also help you make more gold by reducing needless AH searches.